The NPC1 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to NPC1. This antibody recognizes Human antigen. The NPC1 Antibody has been validated for the following applications: Immunohistochemistry.
Description
This gene encodes a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. It is predicted to have a cytoplasmic C-terminus, 13 transmembrane domains, and 3 large loops in the lumen of the endosome - the last loop being at the N-terminus. This protein transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolized and released as free cholesterol